By W. Schramm, H. Krebs (auth.), Professor Dr. med. Inge Scharrer, Professor Dr. med. Wolfgang Schramm (eds.)
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Extra resources for 33rd Hemophilia Symposium: Hamburg 2002
Below 2% and above 2%, is almost similar in patients with hemophilia A and B as shown in Fig. 3. In 3,51% of the patients with hemophilia A and in 2,83% of the patients with hemophilia B, an inhibitor was found (see Fig. 4 and Tab. 2). 28% of patients with von-Willebrand disease showed ristocetin Cofactor levels below 30% as demonstrated in Fig. 5 and Table 2. Factor VIII/IX activity activity up to 2% 45,37% 1823 activity over 2% 54,63% 2195 47,38% 334 52,62% 371 Hemophilia B Hemophilia A Fig. 3.
Krebs Causes of Death In the 2001/2002 period a total of 22 patients were reported dead with the distribution of causes of death given in Table 4. Since the beginning of the survey in 1982 a total of 712 patients have been reported dead. The development of mortality and causes of death since 82/83 are depicted in Fig. 9 to Fig. 11. AIDS, liver disease and cancer have been the main causes of death in this year’s survey. While AIDS and cancer as causes of death remained relative constant, liver disease declined to a level comparable to that of the preceding years.
8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. C. Mühle et al. viously untreated patients with severe hemophilia A after exposure to recombinant factor VIII : incidence of inhibitor and evaluation of immune tolerance. Thromb Haemost 1998; 80: 779–783 Gruppo R, Bray GL, Schroth P, Perry M, Gomperts ED, for the Recombinate PUP Study Group. 5 year update. : PD-663 Lusher JM, Shapiro A, Gruppo R, Bedrosian CL, Nguyen K, the ReFacto PUP Study Group. Safety and efficacy in previously untreated patients (PUPs) treated exclusively with Bdomain deleted factor VIII (BDD rFVIII).