Download Advances in Neurochemistry by Louis Sokoloff (auth.), B. W. Agranoff, M. H. Aprison (eds.) PDF

By Louis Sokoloff (auth.), B. W. Agranoff, M. H. Aprison (eds.)

This sequence has been directed at delivering scientists owning enormous bio­ chemical history with really good studies of neurobiological curiosity. a few have handled accomplished our bodies of study, whereas others include huge experiences of study in growth, judged to be of present curiosity to the energetic researcher. we've got chosen famous scientists and allowed them freedom to mirror and speculate within the box during which they've got accomplished promenade­ inence. We be aware with unhappiness the passing of Dr. 10rdi FoIch-Pi, who served as an advisory editor whilst the sequence was once initiated. He performed a vital function within the improvement of neurochemistry, in addition to the production societies and journals. he'll be remembered fondly via all these whose lives he touched. The editors recognize the cooperation of the Upjohn corporation within the guidance of the colour plate integrated during this quantity. We additionally recognize the skillful editorial suggestions of Dr. Kenneth C. Leskawa. we're happy to honor the retirement of Dr. E. Martin Gal, a former advisory editor of Advances, with the inclusion of a bankruptcy by way of him during this volume.

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These values are presented in Table 3. The rates of local cerebral glucose utilization in the normal conscious rat vary widely throughout the brain. The values in white structures tend to group together and are always considerably below those of gray structures. The average value in gray matter is approximately 50-200 ~mol of glucose/100 g per min. The highest values are in the structures involved in auditory functions, with the inferior colliculus clearly the most metabolically active structure in the brain.

Effects of Thiopental Anesthesia on Local Cerebral Glucose Utilization in the rat a•b Local cerebral glucose utilization (ILmoles/ I 00 g per min) Structure Control' (6) Anesthetized' (8) % Effect Gray matter Visual cortex Auditory cortex Parietal cortex Sensorimotor cortex Lateral geniculate body Medial geniculate body Thalamus Lateral nucleus Ventral nucleus Hypothalamus Caudate-putamen Hippocampus: Ammon's Horn Amygdala Cochlear nucleus Lateral lemniscus Inferior colliculus Superior olivary nucleus Superior colliculus Vestibular nucleus Pontine gray matter Cerebellar cortex Cerebellar nucleus 111 157 107 118 92 126 ± ± ± ± ± ± 5 5 3 3 2 6 64 81 65 67 53 63 108 98 63 III 79 56 124 114 198 141 99 133 69 66 106 ± 3 ±3 ± 3 ±4 ± 1 ±4 ±7 ±7 ±7 ± 5 ±3 ±4 ± 3 ±2 ±4 58 55 43 72 56 41 79 75 131 104 59 81 46 44 75 ± ± ± ± ± ± 3 3 2 2 3 3 ±2 ± I ±2 ±3 ± I ±2 ±5 ±4 ±8 ±7 ±3 ±4 ±3 ±2 ±4 ~42 ~48 ~39 ~43 ~42 ~50 ~46 ~44 ~32 ~35 ~29 ~27 ~36 ~34 ~34 ~26 ~40 ~39 ~33 ~33 ~29 White matter Corpus callosum Genu of corpus callosum Internal capsule Cerebellar white matter 42 35 35 38 ± ± ± ± 2 5 2 2 30 30 29 29 ± ± ± ± 2 2 2 2 ~29 ~I4 ~17 ~24 From Sokoloff et af.

Light halothane anesthesia with or without supplementation with nitrous oxide has been found to be quite satisfactory. At least 2 hr are allowed for recovery from the surgery and anesthesia before initiation of the experiment. 1. lCi of [14C]_ DG per kg of body weight is administered to the animal via the venous catheter. l1 samples of arterial blood are collected consecutively as rapidly as possible during the early period so as not to miss the peak of the arterial curve. Arterial sam ping is continued at less frequent intervals later in the experimental period but at sufficient frequency to define fully the arterial curve.

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