By Luz Romero, Josep Ma Casanovas, Ildefons Hervás, Roser Cortés (auth.), Phil Skolnick (eds.)
In Antidepressants: present developments and destiny instructions, modern investigators distill the dramatic contemporary advances in our realizing of the mechanisms chargeable for antidepressant motion. The authoritative members provide thoughts to enhance present remedies grounded on biogenic amine-based thoughts. by means of departing from conventional techniques, the authors provide possible choices to remedies that frequently paintings too slowly or on no account, and recommend how the numerous contemporary advances in molecular biology and genetics may possibly top be exploited within the layout of optimum new treatments.
Antidepressants: present traits and destiny instructions summarizes novel suggestions of antidepressant treatment that try and take advantage of provocative new insights from the laboratory to enhance present, biogenic amine-based remedies. Readers will locate the e-book a great source in starting the door to the improvement of more recent and more suitable antidepressant therapies.
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Extra info for Antidepressants: New Pharmacological Strategies
And Artigas, F. (1996) Two actions are better than one: avoiding self-inhibition of serotonergic neurones enhances the effects of serotonin uptake inhibitors. Int. Clin. Psychopharmacol. U(Suppl. 4), 1-8. 90. Ahlenius, S. and Larsson, K (1987) Evidence for a unique pharmacological profile of 8-0H-DPAT by evaluation of its effects on male rat sexual behavior, in Brain 5-HT1A Receptors (Dourish, C. , and Hutson, P. ). Ellis Horwood, Chichester, UK, pp. 185-198. 91. Hjorth, S. and Carlsson, A (1985) (-)-Pindolol stereospecifically inhibits rat brain serotonin (5-HT) synthesis.
Transporter and autoreceptors) and heterocontrol mechanisms exerted by excitatory and inhibitory afferents at somatodendritic and terminal level (A and B, respectively, in Fig. 13). Another aspect that deserves current and future attention concerns the postsynaptic changes elicited by enhanced 5-HText after chronic SSRI treatments, and the identification of the receptors involved. Indeed, the administration of drugs acting selectively at certain postsynaptic reC(eptors would induce more rapid and effective improvements by avoiding the self-inhibition of 5-HT neurons during early treatment stages with serotonergic antidepressants (~SRIs, MAOIs, and some TCAs).
Pharmacol. 263,227-234. 46. Rutter, J. , and Auerbach, S. B. (1994) Increase in extracellular serotonin produced by uptake inhibitors is enhanced after chronic treatment with fluoxetine. Neurosci. Lett. 171,183-186. 47. , and Samanin, R. (1994) Chronic treatment with citalopram facilitates the effect of a challenge dose on cortical serotonin output: role of presynaptic 5-HTIA receptors. Eur. 1. Pharmacol. 260, 243-246. 28 Romero et al. 48. , and Samanin, R (1995) Extracellular concentrations of serotonin in the dorsal hippocampus after acute and chronic treatment with citalopram.